Who will look after my sample?
Samples collected in England and Northern Ireland will be managed by the NIHR BioResource, under their contract with the NIHR National Biosample Centre.
Samples collected in Scotland will be managed by the NIHR BioResource or the University of Edinburgh, supervised by Prof Andrew McIntosh, the local Principal Investigator.
Samples collected in Wales will be managed by the NIHR BioResource or Cardiff University, supervised by Prof Ian Jones, the local Principal Investigator.
Will my entire DNA/genome be sequenced?
Your genome is your complete set of DNA. Initially, we won’t be sequencing all of your DNA but instead will specifically look at genetic variations mostly known to be common, but some rare in the population. We will use a DNA microarray to genotype ~650,000 genetic variations that allow us to capture information about >90% of the genome. As technology improves, the project or NIHR BioResource team may sequence all or part of your genetic code, to get improved coverage of rarer genetic variants. All your genetic data will be stored securely in order to allow us to improve our understanding of the development and treatment of anxiety and depression, as well as other health studies, as part of the NIHR BioResource.
Can I access my genetic data?
Genetic data can be fed back if you request it, however please note that the data generated is from a research specific genotyping chip whose content covers just 0.2% of the genome. Returned data will not be in the form of a report, it will be the single nucleotide polymorphism (SNP) calls in a CSV file format. It is also important to understand that this data has been generated by a research pipeline, and is definitely not equal to a clinical or diagnostic NHS test. Data typically takes 12 months to generate.
Will the saliva sample tell you about my ancestry or health?
We are only using the genetic data that we extract from your saliva for general research purposes, to improve healthcare and not for individual clinical diagnoses. In the rare instance that we do find something of clinical importance, we will write to your GP recommending further investigation.
Will I receive information about my results?
The NIHR BioResource Centre Maudsley distributes a biannual newsletter in which we will communicate our findings to members of the GLAD Study. In addition, we will update members of any new findings on the Useful Links page of the GLAD Study.